Summary: The RNA exosome is a versatile ribonuclease.In the nucleoplasm of mammalian cells, it is assisted by its adaptors the nuclear exosome targeting (NEXT) complex and the poly(A) exosome targeting Dugouts (PAXT) connection.Via its association with the ARS2 and ZC3H18 proteins, NEXT/exosome is recruited to capped and short unadenylated transcri
BackgroundThe estimated lifetime risk of stroke was the highest in East Asia worldwide, especially in China.Antihypertensive therapy can significantly reduce stroke mortality.However, blood pressure control is poor.Medication adherence is a barrier as patients’ out-of-pocket costs have risen.We aimed to take advantage of a free hypertension pharm
Abstract A 36-year-old parturient with a suspicion of placenta accreta under tocolytic therapy with ritodrine infusion underwent emergency cesarean section under general anesthesia with propofol, ketamine, and remifentanil because massive bleeding was anticipated.The ritodrine infusion was discontinued 1 h before cesarean section.The baby was deliv
For proper cholesterol metabolism, normal expression and function of scavenger receptor class B type I (SR-BI), a high-density lipoprotein (HDL) receptor, is required.Among the factors that regulate overall cholesterol homeostasis and HDL metabolism, the nuclear farnesoid X receptor plays an important role.Guggulsterone, a bioactive compound presen
Abstract Underground mined-out voids need to be backfilled for the stability of the surrounding rock and also to increase here ore extraction from adjacent pillars.One of the relatively newer means is cemented paste backfilling, which has been extensively adopted in underground mining operations around the world.During and after the placement of ce